Rangers defeated Niger Tornadoes 1-0 on Sunday at Bako Kontagaro Stadium in Minna, with Bashir Usman scoring the game-winning goal.
Three minutes past the half-hour mark, Usman struck.
The holders, who suffered a 1-0 loss to Shooting Stars on the road last week, were back to winning ways.
Sunshine Stars were defeated 2-1 by Ikorodu City in the Mobolaji Johnson Arena in Onikan, Lagos.
Seven minutes before halftime, Shola Adelani gave Ikorodu City the lead, and in stoppage time of the first half, Chigozie Iwundu gave the visitors an equaliser.
Long into stoppage time, Rivio Ayemnwere gave the home team the victory.
In the North West derby, four-time champions Kano Pillars defeated El-Kanemi Warriors 1-0.
Both teams were separated on the day by a goal from Umar Al Amin in the 37th minute.
At Lafia City Stadium, Lobi Stars and Heartland fought to a scoreless tie.
At Muhammadu Dikko Stadium, Katsina United defeated Nasarawa United 1-0, with Azeez Falolu scoring the game-winning goal 17 minutes from the end.
Remo Stars defeated Akwa United 2-1 after a fierce battle, continuing their pursuit of the championship.
After three minutes, Shuaibu Ibrahim gave Remo Stars the lead with a penalty kick.
Late in the first half, Osoba Kabir equalised as the visitors rallied.
Tochukwu However, Michael’s incredible free kick nine minutes from the end gave the home team the victory.
The NPFL continues on Monday with Rivers United hosting Plateau United while Enyimba will play host to Bendel Insurance.
FULL RESULTS
Lobi 0-0 Heartland
Katsina Utd 1-0 Nasarawa Utd
Ikorodu City 2-1 Sunshine Stars
3SC 1-0 Kwara Utd
Remo Stars 2-1 Akwa Utd
Tornadoes 0-1 Rangers
El-Kanemi 1-0 Kano Pillars