Crystal Palace secured a 2-0 win over Manchester United at Old Trafford, with Jean-Philippe Mateta scoring both goals on Sunday.
United’s woes were compounded by a serious injury to defender Lisandro Martinez, who was stretchered off in tears after sustaining a knee injury.
The incident caused a lengthy delay as medics attended to the Argentine international.
Martinez’s injury is a significant setback for United, as the defender previously endured a long spell on the sidelines after breaking his metatarsal in his debut season at the club.
Mateta opened the scoring for Palace in the 64th, putting the visitors ahead.
His second goal came shortly just before full-time.
The loss leaves Manchester United manager Ruben Amorim with mounting concerns, as his side struggles for consistency in the Premier League.